How do I explain a career change in a job interview?

With a clear transition narrative: 1) Why are you leaving your previous industry (frame positively — moving towards, not fleeing from), 2) What competencies do you bring that are transferable, 3) What you have already done to close the gap (courses, projects, networking). The key: Sell your career change as a strength — you bring an outsider's perspective that pure insiders don't have.